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Two Scientists Discover Ineffectiveness of Cold Medicine Ingredient After Years of Research

Two scientists, Randy Hatton and Leslie Hendeles, dedicated nearly two decades to studying the effectiveness of a common ingredient found in cold medicines. The Food and Drug Administration (FDA) has recently acknowledged their findings and deemed the ingredient to be ineffective.

The Scientists’ Journey

Randy Hatton, a pharmacist, and Leslie Hendeles, a Professor Emeritus in the College of Pharmacy at the University of Florida, collaborated on a comprehensive study of over-the-counter cold medications. Their focus was specifically on the ingredient Phenylephrine, commonly used in these medications to relieve sinus congestion and nasal blockage.

Phenylephrine was approved by the FDA for use in over-the-counter products back in 1976. It has been a key component in popular oral cold medicines, including DayQuil Cold & Flu, Advil Sinus Congestion & Pain, and Flonase Headache & Allergy Relief. Some medications, like Sudafed PE Sinus Congestion, even solely rely on phenylephrine as the active ingredient.

Hatton and Hendeles embarked on a quest to prove the effectiveness of phenylephrine, hoping to provide valuable information to consumers and guide them away from ineffective medications. Their research involved rigorous examinations and extensive studies.

The Research Results

After years of dedicated work, Hatton and Hendeles reached a definitive conclusion: phenylephrine does not effectively relieve nasal congestion, despite claims made by manufacturers. Their motivation stemmed from a desire to ensure that individuals who spend their hard-earned money on medications receive products that truly work.

The scientists took their findings to the FDA, urging the agency to take action based on their research. The FDA responded by assembling its own panel to examine the efficacy of oral phenylephrine in unblocking sinuses. In a unanimous decision last month, the panel confirmed that phenylephrine is indeed ineffective.

The Impact and Way Forward

As a result of these findings, CVS Health has permanently removed medications that solely list phenylephrine as their active ingredient from its shelves. This reflects the growing realization among pharmacists and healthcare professionals that the ingredient does not deliver the promised relief.

The breakthrough made by Hatton and Hendeles offers valuable insights for both consumers and healthcare providers. It highlights the importance of critically evaluating the effectiveness of ingredients in common medications.

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