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## Achilles Therapeutics PLC

### Phase I/IIa update
Achilles Therapeutics PLC recently provided an interim Phase I/IIa update on clonal neoantigen reactive T cells in advanced NSCLC and melanoma. The data highlighted improved doses from the VELOS™ manufacturing process and encouraging tolerability. This update has given important mechanistic learnings about the factors driving durable engraftment and immune evasion at an antigen level.

### Enhanced host conditioning
The company is evaluating the benefit of enhanced host conditioning, with further data expected in the second half of 2024. This evaluation aims to understand cNeT persistence and clinical activity in patients with enhanced host conditioning.

### Financial strength
Achilles Therapeutics PLC boasts a strong cash position of $112.3 million, which supports operations through 2025. This financial stability includes completion of the ongoing Phase I/IIa trials and continued development of precision T cell-based products targeting clonal neoantigens.

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### About Achilles Therapeutics
Achilles Therapeutics is a clinical-stage biopharmaceutical company specializing in AI-powered precision T cell therapies targeting clonal neoantigens to treat solid tumors. The company aims to revolutionize cancer treatment by developing personalized therapies based on unique protein markers expressed on the surface of every cancer cell.

### Financial Update
– Cash and cash equivalents: The company holds $112.3 million as of March 31, 2024, supporting planned operations through 2025.
– Research and development (R&D) expenses: R&D expenses decreased to $10.1 million for the first quarter ended March 31, 2024.
– General and administrative (G&A) expenses: G&A expenses decreased to $4.2 million for the same period.
– Net loss: Net loss for the first quarter of 2024 was $12.3 million, reflecting a decrease compared to the same period in 2023.

### 2024 Focus
– Clinical Data: Expected report on clinical activity and translational science data from patients in CHIRON and THETIS Cohort C.
– Translational Science: Leveraging the world-class translational science platform to define features associated with clinical response.
– Manufacturing Development: Focus on VELOS™ and PELEUS™ development to optimize cNeT dose and functionality.

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