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## Anikeeva’s Interest in the Gut-Brain Connection

Anikeeva’s interest in studying the brain-body connection was sparked by a hypothesis proposed by Heiko Braak in 2003, suggesting that Parkinson’s disease could have environmental origins. Braak and his colleagues theorized that a pathogen entering the body through the mouth or nasal cavity could lead to the formation of abnormal protein clumps in neurons within the digestive tract, a condition known as Lewy pathology. This pathology is characteristic of Parkinson’s disease.

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## Anikeeva’s Research in Brain-Body Interfaces

Anikeeva’s lab specializes in developing flexible polymer-fiber probes that can interact with the brain and spinal cord. These probes are used to stimulate and record neuronal signals in mice for studying behavioral patterns. Additionally, the lab explores the use of magnetic nanomaterials to regulate neuronal activity remotely, avoiding the need for invasive procedures.

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### The Brain-Body Connection and Anikeeva’s Artistic Background

Despite Anikeeva’s roots in science, her artistic inclinations and hobbies like climbing and long-distance running play a significant role in her research approach. She utilizes her creative thinking and imagination to conceptualize the design of devices for brain and gut interfaces. This artistic perspective enables her to visualize innovative solutions in her scientific work.

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#### Collaborative Efforts and Breakthrough Discoveries

Anikeeva’s collaborations with researchers at Duke University, particularly with gut-brain neuroscientist Diego Bohórquez, led to significant advancements in exploring the gut-brain connection. By integrating flexible fiber technology and optogenetics, Anikeeva’s team successfully controlled gut functions in mice, demonstrating the potential of their research in understanding neural pathways between the gut and the brain.

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