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## The Relationship Between High-Density Lipoprotein (HDL) Cholesterol and Dementia Risk

Despite being referred to as the ÔÇ£good cholesterolÔÇØ due to its cardiovascular benefits, high-density lipoprotein (HDL) cholesterol has been found to be associated with a potential increased risk for dementia in older individuals with very high levels of HDL. This link was established through a research study published in a Lancet journal, the Lancet Regional Health – Western Pacific. The researchers discovered that individuals with very high HDL levels were more likely to develop dementia compared to those with more optimal levels of HDL. For instance, participants aged 75 or older with high HDL levels were 42 percent more likely to develop dementia than those with normal HDL levels. Furthermore, overall, individuals with high HDL levels had a 27 percent increased risk for dementia.

The study, which spanned over six years and involved 18,668 participants aged 65 or older who were physically and cognitively healthy at the onset of the research, saw 850 participants (4.6 percent) being diagnosed with cognitive dementia during the study period.

The findings regarding the potential detrimental impact of high HDL levels on cognitive health have raised concerns and highlighted the need for further investigation into this association. The researchers noted that the increased dementia risk associated with high HDL levels appeared to be independent of common risk factors for dementia, including physical activity level, alcohol intake, education, diabetes, smoking, and genetic influences. Additionally, the reason for the link between high HDL levels and dementia risk remains unclear, necessitating additional research to understand this connection.

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