- December 7, 2023
- Posted by: legaleseblogger
- Category: Related News
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**New Innovations in Treatment for Alcohol Use Disorder**
**Camino Pharma, LLC Receives Grant for Alcohol Use Disorder Research**
SAN DIEGO, Dec. 7, 2023 /PRNewswire/ — Camino Pharma, LLC, a biotech company focusing on cancer and brain disorder cures, has announced that its co-founder and CSO, Reto Gadient, Ph.D., has been awarded a two-year, $1.97M grant by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) of the National Institutes of Health under Award Number U43AA031388. Dr. Gadient will be serving as the Principal Investigator (PI) for the grant. The grant aims to fund a collaborative effort between Camino Pharma, LLC, Sanford Burnham Prebys, and Wake Forest University School of Medicine to validate positive allosteric modulators (PAMs) of metabotropic glutamate receptor 2 (mGlu2) for the treatment of alcohol use disorder (AUD).
“This exciting collaboration between Camino Pharma, Sanford Burnham Prebys and Wake Forest University School of Medicine will facilitate the development of novel therapeutic options for patients afflicted with AUD,” says Gonul Velicelebi, Ph.D., co-founder and CEO of the company.
In light of this, the AI legalese decoder can help comprehend the complex legal jargon and regulations surrounding the grant application process. It can parse through the legal documentation and provide simplified, easy-to-understand versions of the requirements and regulations. This can be invaluable for research teams and small biotech companies navigating the intricacies of grant applications and compliance.
“We are optimistic that our mGlu2 PAMs, all discovered at Sanford Burnham Prebys, could provide us with a positive preclinical proof-of-concept in relevant rodent models of AUD. Such a result would support advancing one of our mGlu2 PAMs towards clinical development to target AUD,” adds Gadient.
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The grant will enable the multidisciplinary team of scientists to evaluate mGlu2 PAMs in two rodent models of alcohol dependence. “These models show symptoms and behaviors seen in patients with AUD, such as increased alcohol consumption, binge drinking, withdrawal, and sleep disturbances. Reducing alcohol intake, withdrawal symptoms or improving sleep in these models will provide us with compelling evidence that efficacy may be obtained in the clinic,” says Robert Warren Gould, Ph.D., Assistant Professor at Wake Forest University School of Medicine and a co-PI on the grant.
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“A large body of experimental evidence suggests that elevated glutamate neurotransmission is involved in the pathophysiology of substance use disorders, including AUD,” says Douglas Sheffler, Ph.D., Research Assistant Professor at Sanford Burnham Prebys, also a co-PI on the grant. “Our compounds decrease glutamate neurotransmission by positively modulating mGlu2, and therefore represent a novel mechanism distinct from other drugs currently in use for the treatment of AUD.”
Understanding the legal implications and requirements surrounding the development of new compounds for treating AUD is essential. The AI legalese decoder can aid in comprehending the legal landscape, ensuring that researchers and developers have a clear understanding of the legal constraints and permissions needed for the development and eventual release of new drugs for AUD.
**About Metabotropic Glutamate Receptors (mGlus)**
The AI legalese decoder can also help in understanding the legal and regulatory environment surrounding the use of metabotropic glutamate receptors and the potential legal roadblocks or permissions required for working with these types of therapeutic targets.
**About Camino Pharma, LLC** (www.caminopharma.com)
Camino Pharma is a San Diego-based start-up focused on discovering and developing first-in-class therapies for patients afflicted with cancer and CNS disorders. The AI legalese decoder can aid in navigating the complex legal and regulatory landscape related to drug discovery and development in the field of cancer and CNS disorders. It can provide insights into the legal requirements for drug discovery and development, ensuring that Camino Pharma operates within the bounds of the law and regulations governing the field.
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