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**Study Suggests Low-Dose Aspirin May Lower Risk of Type 2 Diabetes in Older Adults**

In a recent study, researchers have found evidence to suggest that low-dose aspirin may reduce the risk of type 2 diabetes in individuals over 65 years of age. This study, which will be presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in October, is a follow-up to the ASPREE trial published in 2018. The ASPREE trial initially reported that low-dose aspirin increased the risk of major hemorrhage in older adults without reducing the incidence of cardiovascular disease.

Led by Professor Sophia Zoungas from Monash University in Australia, the researchers conducted a double-blind, placebo-controlled study to investigate the effects of low-dose aspirin on incident diabetes and fasting plasma glucose levels among older adults. The study included 16,209 participants aged 65 and older who did not have cardiovascular disease, physical disability, or dementia at the beginning of the study. Participants were randomly assigned to receive either 100 mg of aspirin or a placebo daily. The researchers defined incident diabetes as self-reported diabetes, initiation of glucose-lowering medication, or a fasting plasma glucose level of 7.0 mmol/L or higher during annual follow-up visits.

During a median follow-up period of 4.7 years, the study recorded 995 incident diabetes cases, with the aspirin group experiencing a 15% reduction in incident diabetes compared to the placebo group. Furthermore, the aspirin group showed a slower rate of increase in fasting plasma glucose levels. The authors concluded that their findings suggest a potential role for anti-inflammatory agents, such as aspirin, in the prevention of type 2 diabetes. However, they also noted that further research is needed to establish the effects of aspirin on incident type 2 diabetes in older adults.

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