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Breakthrough in Molecular Device Development

In a new breakthrough that could revolutionize medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

The researchers from The University of Manchester describe a force-controlled release system that harnesses natural forces to trigger targeted release of molecules, which could significantly advance medical treatment and smart materials. This groundbreaking discovery, published today in the journal Nature, has the potential to transform the way we approach healthcare and material science.

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The discovery uses a novel technique involving a type of interlocked molecule known as rotaxane. Under the influence of mechanical force – such as that observed at an injured or damaged site – this component triggers the release of functional molecules, like medicines or healing agents, to precisely target the area in need, such as the site of a tumor or a wound.

Furthermore, this breakthrough holds promise for self-healing materials that can repair themselves in situ when damaged, extending the lifespan of these materials. For instance, a scratch on a phone screen could potentially be fixed using this technology.

Efficient Multiple Molecule Release System

Traditionally, the controlled release of molecules with force has presented challenges in releasing more than one molecule at once. The new approach involves two polymer chains attached to a central ring-like structure that slide along an axle supporting the cargo, effectively releasing multiple cargo molecules in response to force application.

The scientists demonstrated the release of up to five molecules simultaneously with the possibility of releasing more, overcoming previous limitations and making it one of the most efficient release systems to date.

Future Applications and Potential

The researchers also show versatility in the model by using different types of molecules, including drug compounds, fluorescent markers, catalysts, and monomers, revealing the potential for a wide range of future applications.

Looking ahead, the researchers aim to delve deeper into self-healing applications, exploring whether two different types of molecules can be released simultaneously. For example, the integration of monomers and catalysts could enable polymerization at the site of damage, creating an integrated self-healing system within materials.

They will also look to expand the range of molecules that can be released, opening up even more possibilities for innovation and advancement in the field.

Unlimited Potential for Technology

Prof De Bo expressed excitement about the future possibilities of this technology, stating, “We’ve barely scratched the surface of what this technology can achieve. The possibilities are limitless, and we’re excited to explore further.” With such enthusiasm and potential, this breakthrough in molecular device development is poised to make a significant impact in various industries and fields.

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