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Introduction to Tooth Regrowth Medicine Clinical Trials

Japanese scientists are making groundbreaking advancements in the field of regenerative medicine by launching the world’s first clinical trials for “tooth regrowth medicine” at Kyoto University Hospital, as reported by The Mainichi.

These innovative trials, led by researchers from the Japanese startup Toregem Biopharma, are specifically targeting individuals born with congenital anodontia, a condition characterized by the absence of some or all teeth from birth.

Utilizing an antibody treatment that targets and deactivates the USAG-1 protein, known to inhibit the development of tooth buds into fully formed teeth, the team aims to provide a novel solution for patients facing tooth loss.

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Expanding the Reach of Tooth Regrowth Treatment

Toregem’s treatment offers hope for individuals who traditionally rely on implants or dentures for restoring their smiles. Co-founder Katsu Takahashi highlighted the significance of this new approach, introducing a potential “third option” for patients, as reported by Nikkei Asia.

While the initial focus is on congenital anodontia cases, the research team aims to extend the benefits of the treatment to individuals experiencing tooth loss due to cavities in the future.

The upcoming Phase 1 trial, set for September, will involve 30 healthy male adults with missing back teeth to evaluate the treatment’s safety. Subsequent Phase 2 trials, planned for the following year, will include young patients aged two to seven with congenital anodontia missing multiple teeth from birth.

Successful Animal Testing and Dentistry Milestones

Prior to the clinical trials, the team conducted promising tests on animals with no adverse effects observed. Ferrets, chosen for their similarities in tooth development to humans, showcased successful growth of new teeth post-treatment assessment in 2018.

Reflecting on the transformative potential of regrowing teeth, Takahashi expressed his long-standing dedication to this pioneering research, emphasizing the significant impact it could have on the field of dentistry.

More on regrowing teeth: Japanese Company Testing Drug to Regrow Teeth in Humans

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