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Study Suggests Gender Differences in Space Resilience

US study suggests gene activity is more disrupted in men, and takes longer to return to normal once back on Earth

Tue 11 Jun 2024 11.00 EDT

When faced with acid-dripping aliens, an untested machine that travels through wormholes, or a space station shattered by hurtling debris, it is the tough female astronaut who steps up to save the day.

And perhaps Hollywood is on to something. A major study into the impact of spaceflight suggests women may be more resilient than men to the stresses of space, and recover more quickly when they return to Earth.

The findings are preliminary, not least because so few female astronauts have been studied, but if the trend is confirmed, it could prove important for astronaut recovery programmes and selecting crews for future missions to the moon and beyond.

"Males appear to be more affected by spaceflight for almost all cell types and metrics," scientists write in a Nature Communications paper that examines the effects of space travel on the human immune system.

Led by Christopher Mason, a professor of physiology at Weill Cornell Medicine in New York, a team of researchers examined how the immune system reacted to space flight in two men and two women who flew around Earth as civilians on the SpaceX Inspiration4 mission in 2021, and compared the findings with data from 64 other astronauts.

The study showed that gene activity was more disrupted in men than women and took longer to return to normal in men once back on terra firma. One protein affected was fibrinogen, which is crucial for blood clotting.

"The aggregate data thus far indicates that the gene regulatory and immune response to space flight is more sensitive in males," the scientists write. "More studies will be needed to confirm these trends, but such results can have implications for recovery times and possibly crew selection, for example more females, for high-altitude, lunar, and deep space missions."

It is unclear why women might be more resilient to spaceflight than men, but Mason said being able to cope with the demands of pregnancy might help. "Being able to tolerate large changes in physiology and fluid dynamics may be great for being able to manage pregnancy but also manage the stress of spaceflight at a physiological level," he said.

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