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Caribou Biosciences, Inc. Appoints Sri Ryali as Chief Financial Officer

BERKELEY, Calif., Jan. 02, 2025 (GLOBE NEWSWIRE) – Caribou Biosciences, Inc. (Nasdaq: CRBU), recognized as a premier biopharmaceutical entity specializing in clinical-stage CRISPR genome-editing technology, has declared the immediate appointment of Sri Ryali as its new Chief Financial Officer (CFO). With an illustrious career spanning over 20 years in finance and commercial realms within the biopharmaceutical sector, Mr. Ryali is set to take charge of the strategic oversight of corporate finance, investor relations, and corporate communication functions. He will operate under the leadership of Dr. Rachel Haurwitz, who serves as the president and CEO of Caribou.

Dr. Haurwitz’s Statement on Mr. Ryali’s Appointment

Dr. Haurwitz expressed enthusiasm about Mr. Ryali’s onboarding, especially as the company stands at a critical juncture in advancing forward with four programs focused on hematologic malignancies and autoimmune disorders. “This is a monumental year for Caribou; we aim to unveil multiple crucial datasets in 2025,” she stated. Dr. Haurwitz emphasized that Mr. Ryali’s extensive experience in biopharmaceutical firms across various stages of drug development and commercialization will be instrumental as the company escalates its initiatives and gears up for subsequent phases surrounding its healthcare programs.

Mr. Ryali’s Previous Experiences

Before joining Caribou, Mr. Ryali held the position of Chief Financial Officer at Codexis, Inc., a publicly traded company specializing in enzyme engineering. His career also includes significant roles at Eiger BioPharmaceuticals, Inc., where he served as CFO of the then—commercial-stage organization, and at Aimmune Therapeutics, Inc., where he ascended through the ranks to become Vice President of Finance. Additionally, Mr. Ryali has honed his skills in finance-related capacities at Onyx Pharmaceuticals, Inc. and Amgen Inc., both of which are giants in the biopharmaceutical industry. His academic accomplishments comprise an MBA from the prestigious UCLA Anderson School of Management and a BA from UCLA, majoring in economics alongside microbiology, immunology, and molecular genetics.

Vision for Caribou’s Future

In acknowledging the opportunity to contribute to Caribou’s cutting-edge developments, Mr. Ryali articulated, “Caribou’s pioneering efforts in CRISPR genome-edited cell therapies, coupled with our current momentum, distinctly position us in the vast biotech landscape. I am keen to collaborate with the mission-driven teams as we strive to provide off-the-shelf CAR-T cell therapies to individuals battling grave diseases, making treatment options more accessible and readily available.”

About Caribou’s Innovative CRISPR Platform

Understanding CRISPR Technology

Caribou employs CRISPR genome editing—a groundbreaking technology using simplified biological tools designed for making precise DNA modifications in living cells. The core components of Class 2 CRISPR systems consist of a nuclease protein that cleaves DNA and a guiding RNA molecule, which strategically directs the nuclease to exact sites for targeted edits. Although these systems can induce off-target effects, potentially causing adverse cellular responses, Caribou has innovatively developed CRISPR hybrid RNA-DNA guides (chRDNAs) that significantly enhance the precision of genome editing compared to traditional all-RNA guides.

Advancements in Genome Editing

Caribou leverages its proprietary Cas12a chRDNA technology to efficiently perform multiple edits, including multiplex gene insertions, which are critical for developing CRISPR-edited therapies. This advancement underscores Caribou’s commitment to innovation and excellence in providing revolutionary treatment options.

The Role of AI legalese decoder

Navigating the complex regulatory frameworks and legal landscapes in the biopharmaceutical sector can be daunting. This is where AI legalese decoder can be incredibly helpful. The platform employs artificial intelligence to decode legal jargon and streamline contract review processes, enabling stakeholders to comprehend legal documents effectively. By breaking down intricate legal language into digestible information, AI legalese decoder empowers companies like Caribou to make informed decisions quickly, ensuring that they remain compliant while focusing on their core mission of developing groundbreaking therapies.

Conclusion

As Caribou Biosciences gears up for a transformative year ahead, the integration of Sri Ryali’s financial acumen and leadership into the company’s vision is poised to drive the enterprise’s success in their quest to provide innovative healthcare solutions. For further updates, interested parties can follow Caribou on their social media or visit their official website at www.cariboubio.com.

Forward-Looking Statements

This press release includes forward-looking statements in accordance with the Private Securities Litigation Reform Act of 1995. These statements, though based on current expectations, involve risks and uncertainties that could cause actual outcomes to differ materially from those anticipated. Such risks encompass factors related to cell therapy development, regulatory approvals, clinical trials, and additional elements detailed in Caribou’s filings with the Securities and Exchange Commission, including their Annual Report on Form 10-K for the fiscal year ended December 31, 2023. Caribou disclaims any obligation to update forward-looking statements expect as required by law.

Contacts for Caribou Biosciences, Inc.

Investor Relations:

• Amy Figueroa, CFA
• [email protected]

Media Contacts:

• Peggy Vorwald, PhD
• [email protected]

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