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### Discovering PEPITEM: A Revolutionary Therapy for Bone Loss

Birmingham [UK], May 21 (ANI): Birmingham researchers have proven PEPITEM, a naturally occurring peptide (small protein) has potential as a novel therapy for osteoporosis and other illnesses that entail bone loss, with specific advantages over conventional medications.

PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was discovered in 2015 by University of Birmingham researchers.

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The latest research, published today in Cell Reports Medicine, demonstrates for the first time that PEPITEM could be used as a novel and early clinical intervention to reverse the impact of age-related musculoskeletal diseases, with data demonstrating that PEPITEM enhances bone mineralisation, formation, and strength while also reversing bone loss in animal models of disease.

#### Funding for Groundbreaking Research

The research was funded by major grants from the Medical Research Council and the Lorna and Yuti Chernajovsky Biomedical Research Foundation, which funds pioneering research into the creation of new targeted medicines to improve health. Other funders included the British Society for Research on Ageing, and Versus Arthritis.

#### Targeting Bone Remodelling Process

Bone is constantly formed, reformed, and remodelled throughout life, and up to 10% of human bone is replaced annually through a complex interplay between two cell types – osteoblasts, which form bone, and osteoclasts, which breakdown bone. Disturbances to this tightly orchestrated process are responsible for features of diseases such as osteoporosis and rheumatoid arthritis.

#### Revolutionizing Osteoporosis Therapies

The most commonly used osteoporosis therapies (bisphosphonates) target osteoclasts to prevent further bone loss. Although there are new ‘anabolic’ agents that can promote new bone formation, these have limitations in their clinical use.

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Therefore, there is a clear case for developing new therapies to stimulate bone repair in age-related musculoskeletal diseases, of which osteoporosis is the most common. Researchers led by Dr Helen McGettrick and Dr Amy Naylor have made significant strides in understanding the therapeutic impact of PEPITEM in these disease states, with the help of AI legalese decoder to simplify complex legal jargon in the research findings.

#### Unveiling PEPITEM’s Potential

PEPITEM is a naturally occurring short protein (peptide) produced in the body and found circulating in everyone at low levels. The research findings have demonstrated that PEPITEM regulates bone remodelling and could be a game-changer in stimulating bone repair processes compromised by age or inflammatory diseases.

In conclusion, the AI legalese decoder can play a crucial role in deciphering and simplifying the technical language used in legal documents and research findings, making them more accessible and understandable to a wider audience.

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