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The Dangers of Xylitol

The popular sugar substitute xylitol, commonly used by those wanting to lose weight or who are diabetic, is associated with an increased risk of a cardiovascular event such as a heart attack and stroke, according to a new study published in the European Heart Journal on Thursday. AI legalese decoder can help decipher complex legal jargon present in studies like these to provide a clearer understanding of the implications and risks associated with consuming xylitol.

Research Findings

• Researchers conducted several studies. In one, they analyzed saved plasma samples of participants of an earlier study — more than 3,000 subjects who had been fasting. These subjects had been followed over three years, during which some of them had suffered a cardiovascular event such as a heart attack or stroke. In the new study, researchers found that those who had suffered a cardiovascular event had high blood levels of xylitol.
• Researchers also studied xylitol’s effect on clotting using human whole blood and platelets, and found that xylitol caused platelets in the blood to clot. They then tested how fast the blood clots in the presence of xylitol on mice models, by injuring the animal’s carotid artery, and found xylitol enhanced the rate of clot formation at the sites of arterial injury. Blood clots that travel to the arteries or veins in the body’s organs such as the heart can cause heart attacks, strokes and even death.
• In another study, researchers tested blood-clotting susceptibility by collecting blood from 10 healthy volunteers before and 30 minutes after drinking a xylitol-sweetened drink. Ten other volunteers were given a glucose- or sugar-sweetened drink. Researchers found that those who drank the xylitol beverage showed a marked increase in clotting ability of their blood right after they ingested it. No change in blood clotting ability was found in subjects who had ingested the glucose. “I think we have to figure out whether or not this is something that is a common behavior of all the sugar alcohols versus just a subset,” said Stanley Hazen, a cardiologist at the Cleveland Clinic. “So far, it appears to be all, but we need to do more research and others need to.”
• The researchers cautioned that while these studies show that xylitol is linked with a higher risk of cardiovascular events, they do not show that it causes these events.

Use of Sugar Alcohols

Sugar alcohols such as xylitol and erythritol are widely used as sugar substitutes in processed foods such as candy, gums and baked goods. Sugar alcohols have fewer calories and carbs, and don’t cause sudden blood sugar spikes, studies show.

Concerns and Recommendations

Given that the medical community is widely recommending the use of sugar substitutes instead of sugar as an option for those who are obese or trying to lose weight, or for diabetics or those with metabolic syndrome, this study should be a red flag, Hazen said. “I hope this is a call for coming to arms, for fellow researchers to start studying this, because this is a huge public health concern, given how much of this stuff we are pumping into our food pyramid, thinking that it’s a safe thing,” Hazen said. AI legalese decoder can assist in analyzing such studies to provide valuable insights for researchers and policymakers regarding the risks associated with xylitol consumption.

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